ginsenoside Rg1, ginsenoside-Rg(1), panaxoside Rg1, sanchinoside C(1), sanchinoside C1
| Name | Ginsenoside Rg1 | ||
| PubChem CID | 441923 | ||
| Molecular Weight | 801.0g/mol | ||
| Synonyms |
ginsenoside Rg1, ginsenoside-Rg(1), panaxoside Rg1, sanchinoside C(1), sanchinoside C1 |
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| Formula | C₄₂H₇₂O₁₄ | ||
| SMILES | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)OC6C(C(C(C(O6)CO)O)O)O)C | ||
| InChI | 1S/C42H72O14/c1-20(2)10-9-13-42(8,56-37-34(52)32(50)30(48)25(19-44)55-37)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+,26+,27-,28-,29+,30+,31-,32-,33+,34+,35-,36+,37-,39+,40+,41+,42-/m0/s1 | ||
| InChIKey | YURJSTAIMNSZAE-HHNZYBFYSA-N | ||
| CAS Number | 22427-39-0 | ||
| ChEMBL ID | CHEMBL501637 | ||
| ChEBI ID | CHEBI:67987 | ||
| Drug Bank ID | DB06750 | ||
| KEGG ID | C08946 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | SanQi | ||
| Use Part | Root | ||
| Habitat | YunNan, GuangXi | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Liver, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax notoginseng
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| Chineses Pinyin | RenShen | ||
| Use Part | Root | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet; Slightly Bitter | ||
| Meridian Tropism | Spleen; Lung; Heart; Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Pair Name | Ginsenoside Rg1, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Up-regulation | Expression | APAF1 | hsa317 | |
| Up-regulation | Expression | ATM | hsa472 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | H2AX | hsa3014 | |
| Down-regulation | Expression | MAPK1 | hsa5594 | |
| Up-regulation | Expression | RAD51 | hsa5888 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Up-regulation | Expression | XRCC1 | hsa7515 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | The present results support the chemosensitizing property of ginsenoside Rg1 in triple-negative breast cancer cell lines. | |||
